Biological experimentation on domestic guinea pigs has been carried out since the 17th century. The animals were used so frequently as model organisms in the 19th and 20th centuries that the epithet guinea pig came into use to describe a human test subject.
Although Ca 2+ overload was postulated as one of the mechanisms for this toxicity, its role was, however, disputable in terms of the contractile dysfunction. In this work, the dynamics of the intracellular Ca 2+ signal were optically mapped in a Langendorff guinea pig heart.
Guinea pigs are utilized as a cholesterol and hypovitaminosis C atherosclerosis model for human research, and guinea pigs with inappropriate diets may develop this condition more commonly than reported.

Under certain housing situations, larger guinea pigs can bully younger guinea pigs. This can cause nutritional deficiencies in those younger guinea pigs. This should be considered when group housing guinea pigs of different sizes.
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Symptoms of Garlic Toxicity. Guinea pigs are highly sensitive to certain foods, and garlic, even in its baby form, can be particularly harmful to them. Garlic contains compounds like n-propyl disulfide and allicin, which can lead to hemolytic anemia in guinea pigs.