bstract ObjectiveTo determine whether lymphocyte apoptosis in intestinal mucosae is more common in healthy dogs than dogs with inflammatory bowel disease (IBD) and whether numbers of apoptotic cells increase after successful treatment of affected dogs. Animals8 dogs with IBD (IBD dogs) and 8 healthy control dogs. ProceduresBiopsy specimens of the duodenum and colon were obtained via ...
... This finding agrees with two studies that evaluated apoptosis in canine IBD, where the expression of Bcl-2 was greater in the duodenum and colon of healthy control dogs versus dogs with IBD and greater numbers of...
In conclusion, apoptosis of T lymphocytes varies within intestinal compartments of dogs with IBD. Mucosal imbalance of Bcl-2/caspase 3 expression favors T cell resistance to apoptosis which may contribute to T cell accumulation and chronic intestinal inflammation, similar to human IBD.
